EXTENDED ABSTRACT: High-throughput preparation is central to high-throughput technology, providing a critical approach for experimental validation and the acquisition of extensive data in materials genome engineering. This paper presents a novel method for high-throughput preparation of large-sized alloy materials using conventional melting and casting techniques, specifically the spiral gradient continuous casting technology. This device has successfully produced large-sized gradient cast bars of Al-Zn-Mg-CuZr, Mg-Zn-Sn-Sr, Zn-Cu-Ti-Ce, and over 50 other binary to quinary aluminum/magnesium/zinc alloy systems. Recent advancements include the production of Zn-Cu-Ti and Zn-Cu-Ti-Mo alloys with compositional gradients using this technology. In situ microbeam X-ray fluorescence (XRF) was used to analyze the chemical composition distribution of these gradient alloys, showing alignment with design expectations. The study also characterized the microstructure, mechanical properties, corrosion resistance, and biocompatibility of these alloys. Analysis of varying Cu, Ti, and Mo contents revealed a Zn alloy with superior mechanical properties and corrosion resistance, featuring a yield strength of 240 MPa, an elongation of 24%, and an Rct of 4227 Ω, suitable for biological implants. Subsequent mouse bone implantation and cytotoxicity tests validated the results, identifying materials appropriate for biodegradable implants. Additionally, high-throughput characterization of MgAlCuZnGd gradient alloys via microbeam XRF demonstrated a gradient distribution of alloy elements. The MgAlCuZnGd lightweight high-entropy alloy was composed of multiple phases, including α-Mg, Al2Gd, MgCuZn, Mg2Cu, and (Mg, Zn)3Gd, and exhibited the highest compressive strength of 474 MPa with moderate ductility (14.0%). High-throughput analysis of Al-7Si-0.5Fe-xSr gradient alloys showed fine and uniformly distributed matrix and precipitates, with excellent mechanical properties, a yield strength between 102 to 116 MPa, an elongation of 15 to 18%, and outstanding corrosion resistance and electrical conductivity. This research demonstrates that the spiral gradient continuous casting method effectively achieves compositional gradients in alloy bars, allowing the simultaneous preparation of multiple alloy samples and facilitating the selection of optimal samples. The technology has evolved to accommodate materials with melting points up to 1700°C, using a vacuum chamber and optimized forming structures, promising large-scale high-throughput preparation of various new materials, including high-melting-point high-entropy alloys, steel, resins, glass, and particle-reinforced composites. This method provides a wealth of data for materials genome engineering, data mining, and machine learning research.
Keywords：Materials Genome Engineering; High-Throughput Preparation; Gradient Alloy Rods;